To understand Hypoxitherapy it is important to recognise the connection between blood circulation, vacuum therapy, exercise and fat loss.  The influence of vacuum therapy on blood circulation is well documented in international science journals and it is common knowledge that blood can be manipulated to targeted areas.

Examples of vacuum therapy being used to manipulate blood flow in medicine:

Wound Management An introduction to the use of vacuum assisted closure. Thomas S. World Wide
Wounds. May 2001.
Abstract

The application of controlled levels of negative pressure has been shown to accelerate debridement and promote healing in many different types of wounds. The optimum level of negative pressure appears to be around 125 mmHg below ambient and there is evidence that this is most effective if applied in a cyclical fashion of five minutes on and two minutes off. It is believed that the negative pressure assists with removal of interstitial fluid, decreasing localised oedema and increasing blood flow. This in turn decreases tissue bacterial levels. Additionally, mechanical deformation of cells is thought to result in protein and matrix molecule synthesis, which increases the rate of cell proliferation. Despite the significant costs involved, the technique is said to compare favourably in financial terms with conventional treatments in the management of difficult to heal wounds.

Mendez-Eastman S. Guidelines for using negative pressure wound therapy. Advances in Skin & Wound Care. 2001; 14(6):314-325

Lower body negative pressure (LBNP) - the application of sub atmospheric pressure to the lower portion of the body.

Changes in superficial blood distribution in thigh muscle during LBNP assessed by NIRS. Hachiya T, Blaber AP, Saito M.  School of Kinesiology, Faculty of Applied Science, Simon Fraser University, Burnaby, British Columbia, Canada.

CONCLUSION: From these results, blood distribution in thigh muscles was different and was affected by the strength of LBNP (Lower Body negative pressure).